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Title: Factors predicting walking intolerance in patients with peripheral arterial disease (PAD) and intermittent claudication
Authors: Parr, Bridget M 
Noakes, Timothy David 
Derman, Wayne 
Keywords: Walking intolerance;Peripheral arterial disease;Intermittent claudication;cardiorespiratory effort
Issue Date: 2008
Publisher: Health and Medical Publishing Group (HMPG)
Source: Parr, B.M., Noakes, T.D. and Derman, W. 2008. Factors predicting walking intolerance in patients with peripheral arterial disease (PAD) and intermittent claudication. South African Medical Journal 98(12): 958 –962
Journal: South African Medical Journal 
Abstract: Objective. To determine which physiological variables conduce to walking intolerance in patients with peripheral arterial disease (PAD). Design. The physiological response to a graded treadmill exercise test (GTT) in patients with PAD was characterised. Setting. Patients were recruited from the Department of Vascular Surgery, Groote Schuur Hospital, Cape Town. Subjects. Thirty-one patients diagnosed with PAD were included in the study. Outcome measures. During a GTT, peak oxygen consumption (VO2peak), peak minute ventilation (VEpeak), peak heart rate and peak venous lactate concentrations were measured and compared with those from a comparison group. Anklebrachial index (ABI) was measured at rest and after exercise. During the GTT, maximum walking distance (MWD) and pain-free walking distance (PFWD) were measured to determine walking tolerance. Results. Peak venous lactate concentrations did not correlate significantly with either PFWD (r=-0.08; p=0.3) or MWD (r=-0.03; p=0.4). Resting ABI did not correlate with either MWD (r=0.09; p=0.64) or PFWD (r=-0.19; p=0.29). Subjects terminated exercise at significantly (p<0.05) lower levels of cardiorespiratory effort and venous lactate concentrations than did a sedentary but otherwise healthy comparison group: peak heart rate 156±11 v. 114±22 beats per minute (BPM); p=0.001; and peak venous lactate concentration 9.7±2.7 mmol/l v. 3.28±1.39 mmol/l; p=0.001. Conclusion. Perceived discomfort in these patients is not caused by elevated blood lactate concentrations, a low ABI or limiting cardiorespiratory effort but by other factors not measured in this study
Description: Article
Appears in Collections:BUS - Journal Articles (DHET subsidised)

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