Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/6515
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dc.contributor.authorNyambuya, MTen_US
dc.contributor.authorDavison, Glenda Maryen_US
dc.contributor.authorHon, Gloudina Maryen_US
dc.contributor.authorKengne, Andre Pascalen_US
dc.contributor.authorErasmus, Rajiv Ten_US
dc.contributor.authorMatsha, Tandi Edithen_US
dc.date.accessioned2018-08-28T13:16:59Z-
dc.date.available2018-08-28T13:16:59Z-
dc.date.issued2018-
dc.identifier.issn1011 5528-
dc.identifier.urihttp://hdl.handle.net/11189/6515-
dc.description.abstractAlthough controversial, hyperglycaemia has been associated with immune dysregulation. We compared the expression of T-cell activation markers in Western Cape hyperglycaemic individuals with matched normoglycaemic controls. Sixty nine participants (86% being women) were included and screened for hyperglycaemia according to World Health Organisation (WHO) criteria. Standard multi-colour flow cytometry was used to measure expression of HLA-DR, CD38, CD95 and PD-1on T-cells at baseline and post incubation with 30mmol glucose. The results were compared and correlated with markers of glucose metabolism and inflammation. The 69 participants included 35 with normal glucose tolerance and 34 with hyperglycaemia. Antigen expression was similar between the two groups. However, after exposure to glucose the percentage of CD4+ T-cells expressing CD95 significantly decreased (p=0.03). There was no correlation with markers of glucose metabolism, but expression did correlate with C-reactive protein. This study in a modest sample group found no relationship between T-cell activation and glucose metabolism, suggesting that other factors such as obesity may be responsible for immune dysregulation. Further studies are required to confirm these findings.en_US
dc.language.isoenen_US
dc.publisherMedical Technology SAen_US
dc.relation.ispartofMedical Technology SAen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/za/-
dc.subjectHyperglycaemiaen_US
dc.subjectObesityen_US
dc.subjectT-cellsen_US
dc.subjectInflammationen_US
dc.subjectType 2 diabetes mellitusen_US
dc.titleT-cell activation and dysfunction in hyperglycaemiaen_US
dc.type.patentArticleen_US
Appears in Collections:HWSci - Journal Articles (DHET subsidised)
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