Please use this identifier to cite or link to this item:
Title: Role of reactive oxygen species in the pathogenesis of cardiovascular disease
Authors: Alinde, O. B. L. 
Esterhuyse, Adriaan J 
Oguntibeju, Oluwafemi Omoniyi 
Keywords: Cardiovascular disease;Reactive oxygen species;Inflammation
Issue Date: 2012
Publisher: Academic journals
Journal: Scientific Research and Essays 
Abstract: Oxidative stress, in recent times, appears to be a major underlying risk factor in the occurrence of major diseases such as cardiovascular diseases (CVD) and inflammatory diseases. During oxidative stress, an overall dysfunction of the balance between the production of reactive oxygen species (ROS) and the antioxidant defence mechanism occurs and a shift is obtained in favour of ROS production. Consequently, this may cause severe molecular, cellular and histological damage of the heart and vascular membranes in both animal and human living system which may lead to more serious complications. Previous studies proposed that reactive oxygen species represent at a molecular basis a key aspect in the pathogenesis of endothelial dysfunction and atherosclerosis which in fact constitute major underlying pathologies of most CVD. In this review, we discuss the role of reactive oxygen species in the pathogenesis of cardiovascular disease.
ISSN: 1992-2248
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

Files in This Item:
File Description SizeFormat 
Role of reactive oxygen species in the pathogenesis.pdfMain article329.61 kBAdobe PDFView/Open
Show full item record

Page view(s)

checked on Feb 9, 2021


checked on Feb 9, 2021

Google ScholarTM


This item is licensed under a Creative Commons License Creative Commons