Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/6384
Title: Role of reactive oxygen species in the pathogenesis of cardiovascular disease
Authors: Alinde, OBL 
Esterhuyse, AJ 
Oguntibeju, OO 
Keywords: Cardiovascular disease;Reactive oxygen species;Inflammation
Issue Date: 2012
Publisher: Academic journals
Journal: Scientific Research and Essays 
Abstract: Oxidative stress, in recent times, appears to be a major underlying risk factor in the occurrence of major diseases such as cardiovascular diseases (CVD) and inflammatory diseases. During oxidative stress, an overall dysfunction of the balance between the production of reactive oxygen species (ROS) and the antioxidant defence mechanism occurs and a shift is obtained in favour of ROS production. Consequently, this may cause severe molecular, cellular and histological damage of the heart and vascular membranes in both animal and human living system which may lead to more serious complications. Previous studies proposed that reactive oxygen species represent at a molecular basis a key aspect in the pathogenesis of endothelial dysfunction and atherosclerosis which in fact constitute major underlying pathologies of most CVD. In this review, we discuss the role of reactive oxygen species in the pathogenesis of cardiovascular disease.
URI: http://hdl.handle.net/11189/6384
ISSN: 1992-2248
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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