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dc.contributor.authorDavison, Glenda Maryen_US
dc.contributor.authorNkambule, Bongani Ben_US
dc.contributor.authorMkandla, Zibusisoen_US
dc.contributor.authorHon, Gloudina Men_US
dc.contributor.authorKengne, Andre Pascalen_US
dc.contributor.authorErasmus, Rajiv Ten_US
dc.contributor.authorMatsha, Tandien_US
dc.description.abstractPlatelet activation has been described in patients with chronic inflammation, however in type 2 diabetes mellitus it remains controversial. We compared levels of platelet leucocyte aggregates, monocyte and granulocyte activation across glucose tolerance statuses in mixed ancestry South Africans. Individuals (206) were recruited from Bellville-South, Cape Town, and included 66% with normal glucose tolerance, 18.7% pre-diabetes, 8.7% screen-detected diabetes and 6.3% known diabetes. Monocyte and neutrophil activation were measured by calculating the percentage of cells expressing CD142 and CD69 while platelet monocyte aggregates were defined as CD14++ CD42b+ events and platelet neutrophil aggregates as CD16++ CD42b+ events. The percentage of monocytes and neutrophils expressing CD69 and CD142 was significantly higher in known diabetes and prediabetes, but, lowest in screen-detected diabetes (both p≤0.016). The pattern was similar for platelet monocyte and neutrophil aggregates (both p≤0.003). In robust linear regressions adjusted for age and gender, known diabetes was significantly and positively associated with the percentage of monocytes expressing CD69 [beta 11.06 (p=0.016)] and CD42b (PMAs) [19.51 (0.003)] as well as the percentage of neutrophils expressing CD69 [14.19 (<0.0001)] and CD42b [17.7 (0.001)]. We conclude that monitoring platelet activation in diagnosed diabetic patients may have a role in the management and risk stratification.en_US
dc.publisherScientific Reportsen_US
dc.relation.ispartofScientific Reportsen_US
dc.subjectPlatelet activationen_US
dc.subjectType 2 diabetes mellitusen_US
dc.subjectSouth African Mixed Ancestry individualsen_US
dc.titlePlatelet, monocyte and neutrophil activation and glucose tolerance in South African Mixed Ancestry individualsen_US
Appears in Collections:HWSci - Journal Articles (DHET subsidised)
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