Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/6368
Title: Hypoxis hemerocallidea significantly reduced hyperglycaemia and hyperglycaemic-induced oxidative stress in the liver and kidney tissues of streptozotocin-induced diabetic male wistar rats.
Authors: Oguntibeju, Oluwafemi Omoniyi 
Meyer, Samantha 
Aboua, Yapo Guillaume 
Goboza, Mediline 
Keywords: Hypoxis hemerocallidea;Southern African regions;Hyperglycaemia;Hyperglycaemic-Induced Oxidative Stress;Liver and Kidney Tissues;Streptozotocin-Induced Diabetic;Male Wistar Rats
Issue Date: 2016
Publisher: Hindawi
Journal: Evidence-Based Complementary and Alternative Medicine 
Abstract: Background. Hypoxis hemerocallidea is a native plant that grows in the Southern African regions and is well known for its beneficial medicinal effects in the treatment of diabetes, cancer, and high blood pressure. Aim. This study evaluated the effects of Hypoxis hemerocallidea on oxidative stress biomarkers, hepatic injury, and other selected biomarkers in the liver and kidneys of healthy nondiabetic and streptozotocin- (STZ-) induced diabetic male Wistar rats. Materials and Methods. Rats were injected intraperitoneally with 50 mg/kg of STZ to induce diabetes. The plant extract-Hypoxis hemerocallidea (200 mg/kg or 800 mg/kg) aqueous solution was administered (daily) orally for 6 weeks. Antioxidant activities were analysed using a Multiskan Spectrum plate reader while other serum biomarkers were measured using the RANDOX chemistry analyser. Results. Both dosages (200 mg/kg and 800 mg/kg) of Hypoxis hemerocallidea significantly reduced the blood glucose levels in STZ-induced diabetic groups. Activities of liver enzymes were increased in the diabetic control and in the diabetic group treated with 800 mg/kg, whereas the 200 mg/kg dosage ameliorated hepatic injury. In the hepatic tissue, the oxygen radical absorbance capacity (ORAC), ferric reducing antioxidant power (FRAP), catalase, and total glutathione were reduced in the diabetic control group. However treatment with both doses improved the antioxidant status. The FRAP and the catalase activities in the kidney were elevated in the STZ-induced diabetic group treated with 800 mg/kg of the extract possibly due to compensatory responses. Conclusion. Hypoxis hemerocallidea demonstrated antihyperglycemic and antioxidant effects especially in the liver tissue.
URI: http://hdl.handle.net/11189/6368
ISSN: 1741-427X
DOI: http://dx.doi.org/10.1155/2016/8934362
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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