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Title: Red palm oil supplementation ameliorates oxidative stress in rats injected with tert-butylhydroperoxide
Authors: Alinde, OBL 
Rooyen, JV 
Oguntibeju, Oluwafemi Omoniyi 
Keywords: Palm oil,;Oxidative stress;Antioxidant;Antioxidative status;Supplementation
Issue Date: 2017
Publisher: African Journals Online (AJOL)
Journal: African Journal of Biomedical Research 
Abstract: Potential benefits of dietary supplementation as quenching agent against oxidative stress-related conditions has been extensively investigated. Red palm oil (RPO), from the tropical plant Elaeis guineensis has captivated much interest in the health sector lately; hence the aim to assess the potential effects of RPO supplementation on the antioxidant status and protection against oxidative damage in experimentally-induced oxidative stress male Wistar rats. Male Wistar rats were randomly divided into four groups (n=5). Rats were fed 0.175g RPO (7g RPO/kg chow) supplementation for 6 weeks. Oxidative stress was induced by intraperitoneal injections of 0.5mL (20µM/100g of body weight) organic tert-butylhydroperoxide (t-BHP). All parameters were determined in plasma and erythrocytes by using appropriate methods. Data were expressed as mean ± SEM. Exposure to t-BHP caused a significant increase in malondialdehydes (MDA) levels in plasma of non-supplemented rats. MDA was significantly reduced by RPO-supplementation. This proved that RPO-supplementation reduced the increase in MDA level induced by t-BHP injection, thereby protecting cellular integrity against induced oxidative stress. Superoxide dismutase (SOD) activity increased significantly (p<0.05) in group supplemented with RPO not induced with oxidative stress. This suggests that RPO supplementation could also improve antioxidant status in a biological system. RPO supplementation offers a protective effect against lipid peroxidation in an oxidative stress-induced biological system and that RPO supplementation had potential benefits in improving antioxidant status.
ISSN: 1119-5096
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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