Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/6260
Title: The role of pollutants in Type 2 Diabetes Mellitus (T2DM) and their prospective impact on phytomedicinal treatment strategies
Authors: Mudumbi, JBN 
Ntwampe, SKO 
Mekuto, L 
Matsha, T 
Itoba-Tombo, EF 
Keywords: Diabetes mellitus;Medicinal plants;PFCs;EDCs;Synergy
Issue Date: 2018
Publisher: Springer
Source: Mudumbi, J.B.N., Ntwampe, S.K.O., Mekuto, L., Matsha, T. and Itoba-Tombo, E.F., 2018. The role of pollutants in type 2 diabetes mellitus (T2DM) and their prospective impact on phytomedicinal treatment strategies. Environmental Monitoring and Assessment, 190(5), p.262.
Journal: Environmental Monitoring and Assessment 
Abstract: Type 2 diabetes mellitus (T2DM) is the most common form of diabetes and it is characterized by high blood sugar and abnormal sera lipid levels. Although the specific reasons for the development of these abnormalities are still not well understood, traditionally, genetic and lifestyle behavior have been reported as the leading causes of this disease. In the last three decades, the number of diabetic patients has drastically increased worldwide, with current statistics suggesting the number is to double in the next two decades. To combat this incurable ailment, orthodox medicines, to which economically disadvantaged patients have minimal access to, have been used. Thus, a considerable amalgamation of medicinal plants has recently been proven to possess therapeutic capabilities to manage T2DM, and this has prompted studies primarily focusing on the healing aspect of these plants, and ultimately, their commercialization. Hence, this review aims to highlight the potential threat of pollutants, i.e., polyfluoroalkyl compounds (PFCs), endocrine disrupting chemicals (EDCs) and heavy metals, to medicinal plants, and their prospective impact on the phytomedicinal therapy strategies for T2DM. It is further suggested that auxiliary research be undertaken to better comprehend the factors that influence the uptake of these compounds by these plants. This should include a comprehensive risk assessment of phytomedicinal products destined for the treatment of T2DM. Regulations that control the use of PFC-precursors in certain developing countries are also long overdue.
URI: https://link.springer.com/article/10.1007/s10661-018-6634-2
http://hdl.handle.net/11189/6260
DOI: https://doi.org/10.1007/s10661-018-6634-2
Appears in Collections:Appsc - Journal Articles (DHET subsidised)

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