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Title: Chemoprevention of azoxymethane-induced colonic carcinogenesis in balb/c mice using a modified pectin alginate probiotic
Authors: Odun-Ayo, Frederick 
Mellem, John 
Naicker, Thajasvarie 
Reddy, Lalini 
Keywords: Azoxymethane;Colonic cancer;Modified citrus pectin;Probiotic;Galectin-3;Immunohistochemistry
Issue Date: 2015
Publisher: Anticancer research
Abstract: Background: Increased intake of probiotic dietary fibre reduces colonic cancer risk. Modified citrus pectin (MCP) requires optimal bioactivity to inhibit galectin-3 (GAL-3) and vascular endothelial growth factor (VEGF). This study evaluated the preventative effect of modified pectin alginate (MCPA) probiotic microbeads on azoxymethane (AOM)-induced colonic carcinogenesis in Balb/c mice. Materials and Methods: Optimization of AOM dose duration: 10-15 mg/kg was administered for 2-4 weeks. The optimal AOM dose was initiated prior to intake of MCPA, alginate probiotic (AP) microbeads and MCP in Balb/c mice for 16 weeks; samples were analyzed for colonic histopathology and immunohistochemistry. Results: AOM at 15 mg/kg for 4 weeks induced optimal GAL-3 and VEGF immunostaining. Furthermore, MCPA treatment reduced GAL-3 expression in the colon of AOM-treated mice compared to MCP. Conclusion: MCPA probiotic microbeads increase bioactivity and chemopreventative effect against pre-cancerous colonic lesions and adenocarcinoma through inhibition of GAL-3 and VEGF in the Balb/c mouse model of colonic carcinogenesis.
ISSN: 4765-4776
Appears in Collections:Appsc - Journal Articles (not DHET subsidised)

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