Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/5776
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dc.contributor.authorRiedel, S-
dc.contributor.authorAbel, Stefan-
dc.contributor.authorBurger, Hester-Mari-
dc.contributor.authorVan der Westhuizen, L-
dc.contributor.authorSwanevelder, Sonja-
dc.contributor.authorGelderblom, W.C.A.-
dc.date.accessioned2017-06-21T14:02:23Z-
dc.date.available2017-06-21T14:02:23Z-
dc.date.issued2016-
dc.identifier.urihttps://doi.org/10.1016/j.plefa.2016.04.006-
dc.identifier.urihttp://hdl.handle.net/11189/5776-
dc.description.abstractDifferential sensitivity of primary hepatocytes and Chang cells to the cancer promoter fumonisin B1 (FB1)-induced cytotoxic effects were investigated in relation to changes in membrane lipid distribution. In contrast to primary hepatocytes, Chang cells were resistant to FB1-induced cytotoxic effects. This was associated with a high cholesterol (Chol) and sphingomyelin (SM) and low phosphatidylcholine (PC) content, resulting in a significant (P<0.05) decrease in phosphatidylethanolamine (PE)/PC ratio, increased Chol/total phosphoglyceride (TPG) ratios and low total polyunsaturated fatty acids (PUFA) content in PC and PE, suggesting a more rigid membrane structure. High levels of C18:1 and reduced polyunsaturated fatty acid (PUFA) levels are likely to provide selective resistance to FB1-induced oxidative stress. FB1-associated lipid changes included decreases in SM and Chol, increases in sphinganine (Sa) and PE with the increases in key saturated, monounsaturated, and PUFAs in PE as key role players in the differential responses to FB1-induced cell growth responses in cells.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/za/-
dc.subjectFumonisin B1en_US
dc.subjectResistanceen_US
dc.subjectLipidsen_US
dc.subjectFatty acidsen_US
dc.subjectCytotoxicityen_US
dc.subjectApoptosisen_US
dc.subjectCell proliferationen_US
dc.titleDifferential modulation of the lipid metabolism as a model for cellular resistance to fumonisin B1–induced cytotoxic effects in vitroen_US
dc.type.patentArticleen_US
Appears in Collections:HWSci - Journal Articles (DHET subsidised)
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