Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/5766
Title: High molecular weight adiponectin levels are neither influenced by adiponectin polymorphisms nor associated with insulin resistance in mixed-ancestry hyperglycemic subjects from South Africa
Authors: Zemlin, Annalise E 
Matsha, Tandi 
Kengne, Andre Pascal 
Hon, Gloudina Mary 
Erasmus, Rajiv T 
Keywords: HMW-adiponectin;Hyperglycemia;Cardio - metabolic traits;Polymorphisms
Issue Date: 2016
Publisher: Journal of Medical Biochemistry
Abstract: Background: High molecular weight (HMW) adiponectin has antiatherogenic, antiinflammatory and antidiabetic properties and these effects have been linked to its effect on high density lipoprotein cholesterol (HDL-c). Single nucleotide polymorphisms (SNPs) in the adiponectin gene influence adiponectin levels. We examined the relationship between HMW-adiponectin levels and cardiometabolic traits in normo- and hyperglycemic mixed ancestry South Africans and correlated these levels to two common polymorphisms. Methods: HMW-adiponectin was determined in 101 subjects from the Cape Town Bellville South community-based study on a mixed ancestry population. Comparisons were made between individuals with normo- and hyperglycemia. Two common SNPs, ADIPOQ SNPs rs17300539 and rs266729, known to affect adiponectin levels were also tested for. Levels of HMW-adiponectin were then correlated with cardiometabolic traits in all groups. Results: Levels of HMW-adiponectin were not significantly different in the normo- and hyperglycemic groups (median 11.6 vs. 10.5 mg/mL, p=0.3060) and in men and women (8.44 vs. 11.34 mg/mL, p=0.67). ADIPOQ SNPs rs17300539 and rs266729 did not influence levels of HMW-adiponectin. Robust correlation analyses revealed a significant positive correlation between HMW-adiponectin and HDL-c (r=0.45; 95%CI: 0.27–0.59), similarly in normo- and hyperglycemic participants (p>0.99). This association was substantially attenuated in robust linear regressions adjusted for age, gender and adiposity. Conclusions: Adiponectin levels in this population were not determined by the commonest SNPs of the adiponectin gene, were unaffected by glycemic status; but were significantly correlated with HDL-c levels. Previous studies have attributed some of the beneficial effects of adiponectin to its effect on HDL-c.
URI: http://dx.doi.org/10.1515/jomb-2016-0024
http://hdl.handle.net/11189/5766
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

Show full item record

Page view(s)

37
Last Week
0
Last month
0
checked on Jul 17, 2019

Download(s)

8
checked on Jul 17, 2019

Google ScholarTM

Check


This item is licensed under a Creative Commons License Creative Commons