Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/5624
Title: Impact of mammaprint on clinical decision-making in South African patients with Early-Stage Breast Cancer
Authors: Pohl, H 
Kotze, MJ 
Grant, KA 
van der Merwe, L 
Pienaar, FM 
Apffelstaedt, Justus.P 
Myburgh, EJ 
Keywords: Mammaprint;Adjuvant chemotherapy;Breast cancer;Genomic profiling;Impact
Issue Date: 2016
Publisher: Wiley
Abstract: The aim of the study was to evaluate the impact of MammaPrint on treatment decision-making in patients with breast cancer. Clinicopathologic information of all breast cancer patients referred for MammaPrint testing in South Africa was collected from 2007 until 2014. A total of 107 patients (109 tumors) with estrogen receptor/progesterone receptor positive and human epidermal growth factor receptor-2 negative tumors were selected with tumors ≥10 mm, or when 1-3 nodes were involved without extra-nodal extension. None of the clinical indicators correlated significantly with the MammaPrint risk classification, which changed the decision for adjuvant chemotherapy in 52% of patients. Of 60 patients who were clinically high risk, 62% had a low-risk MammaPrint result and of the 47 clinically low -risk patients 40% had a high-risk MammaPrint result. This study indicates that MammaPrint could reduce the need for adjuvant chemotherapy by 17% using the selection criteria stipulated. The significant impact on treatment decisions confirmed the clinical utility of MammaPrint independent of standard clinicopathologic risk factors as supported by long-term clinical outcome studies.
URI: http://dx.doi.org/10.1111/tbj.12605
http://hdl.handle.net/11189/5624
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

Files in This Item:
File Description SizeFormat 
Pohl_H_Kotze_MJ_Grant_KA_van_der_Merwe_L_Pienaar_FM_Apffelstaedt_JP_Myburgh_EJ_Health & Well_2016.pdfMain Article350.17 kBAdobe PDFView/Open
Show full item record

Page view(s)

23
Last Week
0
Last month
2
checked on Aug 20, 2019

Download(s)

17
checked on Aug 20, 2019

Google ScholarTM

Check


This item is licensed under a Creative Commons License Creative Commons