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Title: Monounsaturated fatty acids in blood cell membranes from patients with multiple sclerosis Inflammation
Authors: Hon, Gloudina Mary 
Hassan, Mogamat Shafick 
Van Rensburg, Susan Janse 
Abel, Stefan 
Erasmus, Rajiv T 
Matsha, Tandi Edith 
Keywords: C-reactive protein;Kurtzke expanded disability status scale;Monounsaturated fatty acids;Multiple sclerosis
Issue Date: 2011
Publisher: Springer
Source: Hon, G.M., Hassan, M.S., van Rensburg, S.J. et al. Inflammation (2011) 34: 681. doi:10.1007/s10753-010-9279-z
Abstract: The aim of this study was to investigate whether blood cell membrane monounsaturated fatty acids were associated with inflammation and disease outcome in patients with multiple sclerosis. The fatty acid composition in peripheral blood mononuclear cell and red blood cell membranes from 26 patients and 25 controls were determined by gas chromatography. Results showed positive associations between C-reactive protein and C16:1n-7, C18:1n-7, and C24:1n-9 in membranes from controls only. In general, C18:1n-9 and C20:1n-9 showed inverse correlations, while C16:1n-7 and C18:1n-7 showed positive correlations with disease outcome. Multiple sclerosis has a known inflammatory component. There is scarcity of literature on the role of monounsaturated fatty acids in inflammation, but results from this study suggested an association in healthy subjects between monounsaturated fatty acids and C-reactive protein, even at physiologically low levels. This association was not found in the plasma from patients. Furthermore, the n-9 and n-7 fatty acids played different roles in disease outcome, and therefore warrant inclusion, together with polyunsaturated fatty acids when investigating the inflammatory aspects of the disease.
Appears in Collections:HWSci - Journal Articles (DHET subsidised)
Prof. Thandi Matsha

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