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Title: Melting point–solubility–structure correlations in multicomponent crystals containing fumaric or adipic acid
Authors: Batisa, Eustina 
Ayamine, Alban 
Kilinkissa, Ornella EY 
Báthori, Nikoletta B 
Keywords: Multicomponent crystals;Fumaric acid;Adipic acid;Cocrystallisation;Pharmaceutical cocrystals
Issue Date: 2014
Publisher: CrystEngComm
Source: CrystEngComm, 2014, 16, 9992
Abstract: This study investigates the relationships between the supramolecular structure and the solubility and melting point of six multicomponent crystals involving fumaric acid (FUM series) and adipic acid (ADI series). The crystals were prepared by solvent evaporation and fully characterised by thermal and diffraction techniques. In each series the melting points of the multicomponent crystals are lower than the relevant carboxylic acid and they show partial correlation with their aqueous solubilities. With the aid of Hirshfeld surface analysis, the relationships between solubility, melting point and the supramolecular structure are discussed.
Appears in Collections:Appsc - Journal Articles (DHET subsidised)

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