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Title: Lysosomal membrane stability of the mussel, mytilus galloprovincialis (L.), as a Biomarker of Tributyltin Exposure.
Authors: Okoro, HK 
Snyman, RG 
Fatoki, Olalekan S 
Adekola, Folahan A 
Ximba, Bhekumusa J 
Slabber, MY 
Keywords: Tributyltin;Mussel;Neutral red retention time;Lysosomal membrane stability;Biomarker
Issue Date: 2015
Publisher: Springer Science and Business Media New York
Source: Okoro, H.K., Snyman, R.G., Fatoki, O.S., Adekola, F.A., Ximba, B.J. & Slabber, M.Y. (2015). Lysosomal membrane stability of the mussel, mytilus galloprovincialis (L.), as a Biomarker of Tributyltin Exposure. Bulletin of Environmental Contamination and Toxicology, 94(5):609-613.
Abstract: The effect of tributyltin (TBT) on the stability of hemocytic lysosome membranes of the mussel, Mytilus galloprovincialis, and the use thereof as a biomarker of TBT-induced stress, was investigated. Mussels were exposed to 0.1 and 1.0 µg/L tributyltin respectively for 4 weeks. Lysosomal membrane stability of hemocytes was tested weekly by means of the neutral red retention time (NRRT) assay, after which the mussel samples were analyzed for TBT content. The two exposed groups exhibited significantly increased (p < 0.05) whole body TBT concentrations with concomitant significant decreases (p < 0.05) in NRRT (R2 values of 0.85 and 0.971 for lower and higher exposure groups, respectively). The higher exposure group showed a typical dose–response curve. For the control, no TBT was detected and NRRT remained stable. It was concluded that the NRRT assay could be considered as a useful technique, and lysosomal membrane destabilization a useful early warning and cellular biomarker of stress due to TBT exposure in M. galloprovincialis.
ISSN: 0007-4861
Appears in Collections:Appsc - Journal Articles (DHET subsidised)
Prof. Bhekumusa Jabulani Ximba
Prof. Olalekan S. Fatoki

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