Please use this identifier to cite or link to this item: http://hdl.handle.net/11189/2846
Title: Protective effects of rooibos (Aspalathus linearis) and/or red palm oil (Elaes guineensis) supplementation on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in Wistar rats
Authors: Ajuwon, Olawale Razaq 
Katengua-Thamahane, Emma 
Van Rooyen, Jacques 
Oguntibeju, Oluwafemi Omoniyi 
Marnewick, Jeanine L 
Issue Date: 2013
Source: Ajuwon, O. R., Katengua-Thamahane, E., Van Rooyen, J., Oguntibeju, O. O., & Marnewick, J. L. (2013). Protective effects of rooibos (Aspalathus linearis) and/or red palm oil (Elaeis guineensis) supplementation on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in Wistar rats. Evidence-Based Complementary and Alternative Medicine, 2013.
Abstract: The possible protective effects of an aqueous rooibos extract (Aspalathus linearis), red palm oil (RPO) (Elaeis guineensis), or their combination on tert-butyl-hydroperoxide-(t-BHP-)induced oxidative hepatotoxicity in Wistar rats were investigated. tert-butyl hydroperoxide caused a significant () elevation in conjugated dienes (CD) and malondialdehyde (MDA) levels, significantly () decreased reduced glutathione (GSH) and GSH : GSSG ratio, and induced varying changes in activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase in the blood and liver. This apparent oxidative injury was associated with histopathological changes in liver architecture and elevated levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH). Supplementation with rooibos, RPO, or their combination significantly () decreased CD and MDA levels in the liver and reduced serum level of ALT, AST, and LDH. Likewise, changes observed in the activities of antioxidant enzymes and impairment in redox status in the erythrocytes and liver were reversed. The observed protective effects when rooibos and RPO were supplemented concomitantly were neither additive nor synergistic. Our results suggested that rooibos and RPO, either supplemented alone or combined, are capable of alleviating t-BHP-induced oxidative hepatotoxicity, and the mechanism of this protection may involve inhibition of lipid peroxidation and modulation of antioxidants enzymes and glutathione status.
URI: http://dx.doi.org/10.1155/2013/984273
http://hdl.handle.net/11189/2846
Appears in Collections:HWSci - Journal Articles (DHET subsidised)

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