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Title: Three-year’s changes in glucose tolerance status in the Bellville South cohort: Rates and phenotypes associated with progression
Authors: Matsha, Tandi Edith 
Soita, David J 
Hassan, Mogamat Shafick 
Hon, Gloudina Mary 
Yako, Yandiswa Y 
Kengne, Andre Pascal 
Erasmus, Rajiv T 
Keywords: diabetes mellitus;risk factors;metabolic syndrome;glucose tolerance;progression;South Africa
Issue Date: 2013
Source: Matsha, T. E., Soita, D. J., Hassan, M. S., Hon, G. M., Yako, Y. Y., Kengne, A. P., & Erasmus, R. T. (2013). Three-year's changes in glucose tolerance status in the Bellville South cohort: Rates and phenotypes associated with progression. Diabetes research and clinical practice, 99(2), 223-230.
Abstract: Aims: To determine the phenotypes associated with progression to type 2 diabetes or worsening in glucose tolerance during a 3-year follow-up of a community-based cohort in Cape Town, South Africa. Methods: A total of 198 eligible subjects (72.3% women) aged 55.2 years, from the Bellville-South community were followed-up between 2008 and 2011. Baseline and follow-up data collections included glucose tolerance status, anthropometric, blood pressure, lipids, insulin, γ-glutamyltransferase, cotinine, creatinine and HbA1c. Progression in glucose tolerance status at 3-year was the composite of new-onset diabetes and any worsening in glucose tolerance status. Results: The cumulative incidence of progression in glucose tolerance status was: 16.2% (32 participants including 11 with new-onset diabetes), and increased in a stepwise fashion with the number of components of metabolic syndrome (MetS). In age and sex-adjusted logistic regression analyses, MetS [odd ratio: 3.08 (95% CI: 1.34–7.10)], HbA1c [5.26 (1.94–14.24)], HDL-cholesterol [0.05 (0.01–0.33)], γ-glutamyltransferase [1.99 (1.07–3.67)], triglycerides [1.71 (1.13–2.58)] and total/HDL-cholesterol [1.45 (1.08–1.93)] were significant predictors of progression, while borderline effects were observed for baseline glucose and diastolic blood pressure. Markers of adiposity were mostly stable or improved among non-progressors during follow-up, but deteriorated significantly among progressors, resulting in significant statistical interactions. Conclusions: High rates of deterioration of glucose status over time were found in our population, with nearly one-fifth of them acquiring a glucose tolerance worse status within a very short follow-up. Our study extends to this setting the well-known utility of phenotypes of MetS single or in combination, in predicting worsening in glucose tolerance status.
ISSN: 0168-8227
Appears in Collections:HWSci - Journal Articles (DHET subsidised)
Prof. Thandi Matsha

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