Please use this identifier to cite or link to this item:
Title: Antioxidant activity and cytotoxicity of the leaf and bark extracts of Tarchnanthus camphorates
Authors: Nanyonga, SK
Opoku, A
Lewu, F
Oyedeji, OO
Singh, M
Oyedeji, AO
Keywords: Tarchonanthus camphoratus;Antioxidant activity;Cytotoxicity
Issue Date: 2013
Source: Nanyonga, S.K., Opoku, A.R., Lewu, F.B., Oyedeji, O.O., Singh, M. & Oyedeji, A.O. 2013. Antioxidant activity and cytotoxicity of the leaf and bark extracts of Tarchonanthus camphorates. Tropical Journal of Pharmaceutical Research, 12(3): 377-383.
Abstract: Purpose: To investigate the antioxidant potential and cytotoxicity of the leaf and bark extracts of Tarchonanathus campharatus. Methods: The antioxidant activity of the aqueous leaf extract (Aq LF), methanol leaf extract (MET LF), dichloromethane leaf extract (DCM LF), methanol bark extract (MET BK), dichloromethane bark extract (DCM BK), and ethyl acetate bark extract (Et Ac BK) were examined by 1,1-Diphenyl-2-picryl-hydrazil (DPPH), 2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS.+), nitric oxide radical scavenging, reducing power and iron chelating activity methods. Brine shrimp lethality and MTT cytotoxicity tests were used to investigate the cytotoxicity of the extracts. Results: The Aq LF, DCM LF, MET LF and MET BK showed good DPPH, ABTS radical scavenging and total reducing power activities. Total reducing power was high and in the rank order of DCM LF > Aq LF > MET LF > MET BK. All the extracts, however, showed weak nitric oxide scavenging activity as well as weak iron chelating ability. Flavonoids, phenols, tannins and saponins were present in some of the extracts, but alkaloids, terpenoids, cardenolides and cardiac glycosides were absent in all the extracts. All the extracts did not show significant cytotoxic properties (p ≥ 0.05) with 50% inhibitory concentration IC50 values > 30 μg/ml in both cytotoxicity assays. Conclusion: The antioxidant activity and low cytotoxicity of Tarchonanthus camphoratus probably justify its use in folk medicine
Appears in Collections:Appsc - Journal Articles (DHET subsidised)

Files in This Item:
File Description SizeFormat 
Nanyonga_SK_Opoku_A_Lewu_F_Oyedeji_OO_Singh_M_Oyedeji_AO_AppSci_2013.pdfMain Article304.6 kBAdobe PDFView/Open
Show full item record

Page view(s)

Last Week
Last month
checked on Sep 20, 2018


checked on Sep 20, 2018

Google ScholarTM


This item is licensed under a Creative Commons License Creative Commons