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Title: Salts of (+)-deoxycholic acid with amines : structure, thermal stability, kinetics of salt formation, decomposition and chiral resolution†
Authors: Jacobs, A 
Bathori, NB 
Nassimbeni, LR 
Sebogisi, BK 
Keywords: Deoxycholic;Acid;Salts;Crystals
Issue Date: 2013
Source: acobs, A., Báthori, N.B., Nassimbeni, L.R. & Sebogisi, B.K. 2013. Salts of ( )-deoxycholic acid with amines: structure, thermal stability, kinetics of salt formation, decomposition and chiral resolution. CrystEngComm, 15(5): 931-939.
Abstract: (+)-Deoxycholic acid forms salts with 1-propylamine, di-n-butylamine, sec-butylamine and 3-methyl-2- butylamine. The salts were characterised using thermal analysis and single crystal X-ray diffraction. The chiral discrimination of (+)-deoxycholic acid for racemic sec-butylamine and racemic 3-methyl-2- butylamine was studied and correlated with the structural and thermal results. A mixture of (+)- deoxycholic acid and racemic sec-butylamine yielded crystals of (R)-2-butylammonium deoxycholate. (+)- Deoxycholic acid was exposed to vapours of propylamine and racemic sec-butylamine and the kinetics of absorption were determined. The kinetics of decomposition of powdered samples obtained from (+)- deoxycholic acid with di-n-butylamine and racemic sec-butylamine were investigated. Crystallisation of (+)- deoxycholic acid with racemic 3-methyl-2-butylamine resulted in crystals of (S)-3-methyl-2-butylammo- nium deoxycholate.
Appears in Collections:Appsc - Journal Articles (DHET subsidised)

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